That may be true in the long run, but that's not the reason these days. I'm convinced that there was some type on non-active ingredient in the original pharmaceutical versions, because you never heard anyone complain of appetite issues. In fact, it would be just the opposite! Maybe there was an enteric coating, I don't know, but something was different.
One thing I found interesting, something I read roughly 10 years ago, has to do with a patent running out. When that happens and other manufacturers can start to produce a generic version, the original manufacturer only has to give them a list of the ingredients. Think of this as a recipe. It makes a difference how you prepare a meal and when certain ingredients are added. The article made the same correlation regarding the list of ingredients for a drug. Is that the case here, I don't know. All I know is that loss of appetite was never an issue.
There's an ADHD med that my son has. Name brand and generic have exactly the same active ingredient and dose (USA). Doctor will tell you flat out that 5% of patients have some kind of issue - major behavioral - with generic due to a binder or coating that should not matter but does. If it shows up, generally early, they will write for name brand. And I've seen it happen first hand - total one off shit show, crazy and unique. Moved to brand name and never ever happened again (like a decade and increased dosage too). Likely something to it in some orals too.
Anyway a lot of guys who were fine with even UGL orals get worse with them as they age. It's all over on this forum. Luckily that's not me. Only issue I've found is even 12.5mg of dbol makes me really tired now after a week. Crazy, used to love it. Now I'm a winny, drol and var guy only. Liked drol better anyway but so many fond memories of the 5mg Russian dbol days...that and some fina/tren brew was kind of magic in the gym.