There are risks to each of these drugs. I've written about them variously on this board.
ARBs:
1. Renal disease and failure
2. Hypotension, including risk of falls and coma, death
3. Diminished hypertrophy
Particularly when used "prophylatically," in those who do not have hypertension.
See:
SGLT-2 inhibitors:
1. Renal failure
2. Hypotension, including risk of falls, coma, death
3. Hyperlipidemia (increased LDL)
Given the overlap of these particular severe side effects with not only one another (hazarding us to
not combine them) & with not
merely elevated, but indeed
compounded risks for bodybuilders, I'd go ahead and say it's unwise to combine these "prophylactically"
under any circumstance.
These drugs are used to treat medical conditions, disorders, diseases, pathologies. Not for (respectably & respectfully bro) jacked guys on social media to promote to healthy bodybuilders.
Interventions, when rational, are judged by a balancing of tradeoffs – to wit, Risks versus Rewards.
Risks are probabilistic, a function of probability * severity. To rationally consider the use of any PED (an intervention), one must be at least able to think in terms of
expected value, a concept from probability & statistics. Until you apply expected value, at least roughly, using at least fuzzy logic, to a decision (that necessarily involves some tradeoff), your decisionmaking about using any drug is probably pretty
terrible.
At the heart of the issue, often, as here, is that people – including notably, you, bro! – don't even
understand the risks of what you are promulgating here as "God's gift to bodybuilders."
Note: What I am
not saying: ARBs & ACE inhibitors aren't fantastic first-line treatments
for hypertension (see links above), and/or that SGLT-2 inhibitors aren't useful for bodybuilders that are hyperglycemic. I've also written about SGLT-2 inhibitors with special reference to the continuum of rhGH adjuvants (moving along the continuum from least to most potent and from glucose disposal to increased IGF-I bioavailability). SGLT-2 inhibitors are discussed in
Bolus: A Practical and Reference Guide for the Use of Recombinant hGH and GH Secretagogues [available soon], in the Practical section, that discussed protocols, adjuvant drugs, and principles, and use cases.