Being 50 I think about this often. I always said I would downsize to 200 for longevity purposed when I approached 50. Well as I approached 50, other than orthopedic shit everything looked great- CAC, BP, lipids, kidneys, stress echo, etc.
I guess the question is when 1 or more important markers takes a nose dive then how does that person react to their usage and health. Hopefully I won't have to cross that bridge but it's always there in my mind. So the important takeaway is do as much as you can with support supps and Pharma supps to continue to do it as "healthy" as possible.
Some people are against using things prophylactically but I fee that it's important to stop the issues before it starts especially if you plan to use past 45 or 50- daily Cialis, Telmisartan, Statin and/or ezitimibe, SGLT2's.