Keep in mind that regardless of its actual half life, IGF-1 levels remain elevated in humans with a single oral dose for about 24 hours.
Thanks for replies.
Yes true, but compared to nothing at all. To my knowledge one dose stimulates GH pulse amplitudes about 12h so twice daily dosing should propably rise IGF-1 more I guess? I am wondering there might be some treshold value like 2-5mg when it starts to working and values under that do not produce much of an effect?
So if one takes 10mg at 3pm before training there will be left something like 2mg from MK before sleep.. so I guess that will not boost night time Gh very much. At least not as much as 10mg added on top of it. So that is why I prefer to take 10mg before bed also as after training those high GH pulses imo are beneficial even more beneficial than high systemic IGF; not sure though. But I think this twice daily might rise IGF-1 also more. I take it with niacin and citicoline during day, and with arginine+lysine, glycine and niacin at night too. If I would take my 20mg before training then there might be bigger pulse during training but the night time pulse wouldn't be enhanced so much as Mk might go under treshold value to have negligible effects on gh pulse. It was noted in studies that when given before bed it raised IGF-1 more than when given at morning but I have not find any studies where they would have given twice daily. Or even more often like it is done with peptides or even injectable long acting steroids nowdays.
So that is why I prefer to dose it twice daily. I have used this about two weeks like this with dianabol 10mg day and anavar 10mg day. I started them all after I ended my fast and so far muscle gains has come steadily and daily. A total of allmost 30lbs lean tissue gained in little under 3 weeks time and water retention is minimal as I have eaten quite low carb, used Telmisartan and also t3 quite high doses (30-50ug). Myostatin goes so low after fast and enables those chemicals and food to work wonders.
I will soon (in about three weeks) go to lab to check how high pulse amplitude will be generated from 10mg of MK-677, when taken in 1h before resistance training with 5mg dbol + 5mg anavar + 1500mg niacin + some citicoline (and normal/high trt). Maybe also add some propral to further inhibit fat burning and some GABA. On a fasted state of course (either after 3 days of fast or 24h of fast - not sure yet.)
Mk-677 will stimulate pituitary release of prolactin also. You do not want that to be constantly elevated.
Thank you for your reply. That is interesting. I didn't know it will boost that to any significant degree. At least (I am speaking now from subjective experience) it feels to me more that MK raises dopamine and activates mesolimbic reward pathway same way as ghrelin is supposed to do to keep us alive - so it has to activate dopamine too to activate us. So even if it raises prolactin I wonder it raises dopamine more or at least activates dopamine pathways to quite significant degree at least in mesolimbic pathway (where there is a lot of ghrelin receptors) leading to activation of ex. nucleus accubens but also mesocortical pathway to enhance function or prefrontal cortex (to the point of being actual nootropic substance IMO) to counterbalance that possible prolactin raise.
At least I've not felt or seen any prolactin issues. It feels more dopaminergic to me. I have Quetiapine and some other sleep aids (dopamine antagonists) that significantly block dopamine and they cause a more significant raise in prolactin so that you might develop breast issues or something. And that dopamine depletion you can also notice very clearly. But those kind of things has not happened with MK but feels more like the opposite to me even though I have used it quite a lot in the past.
So I guess at least in my case prolactin is not an issue. I also use citicoline with Mk to boost GH pulse and it should upregulate D1 receptors and might mitigate possible prolactin raise with MK (it might actually lower prolactin in some cases [1]). But I guess my quetiapine raises more prolactin than Mk. I use also nicotine chronically too which should counterbalance that..
[1]
The effect of intravenous infusion of cytidine diphosphate choline (CDP-choline) on the serum levels of growth hormone (GH) and prolactin (PRL) was studied in six normal adult male subjects. Serum GH levels increased and reached a maximum at 60--90 min after the initiation of infusion in all...
pubmed.ncbi.nlm.nih.gov